Reduced skin permeation and penetration of clobetasol propionate when Dermovate cream is applied at short time intervals with emollients

Background Dermovate cream containing 0.05% clobetasol propionate is a very potent topical corticosteroid (TCS) used in the treatment of severe inflammatory dermatoses. Regular emollient therapy should continue alongside treatment, however, impact on drug delivery to skin when both products are applied at similar times unknown. Objectives To assess whether application emollients alter skin. Methods This study was conducted using ex vivo human mounted Franz cells. before or after three different emollients, Hydromol Intensive cream, Doublebase gel, and Diprobase ointment 5- 30-min intervals. Drug assessed up 24 h high-performance liquid chromatography. Results Significantly reduced observed either compared alone. The data suggest situ formation mixed layer which reduces relative original product. Applying any generally resulted larger reductions skin, steroid first. attributed forming an additional barrier skin-formulation interface. Conclusions These findings indicate that applying as can significantly reduce separating two by intervals 30 min not sufficient mitigate this effect.